Abstract | PURPOSE: METHODS: RESULTS: Twenty-one patients were enrolled. From eight patients, serial WS samples and simultaneous plasma samples were obtained within a dosage interval. AFG concentrations in WS amounted to < 0.025-2.25 mg/L, MFG concentrations were 0.025-2.53 mg/L, and CAS achieved concentrations of 0.18-4.04 mg/L. Concentrations in WS were significantly lower than the simultaneous plasma concentrations and below the MIC values of some relevant pathogens. CONCLUSION:
Echinocandin penetration into WS displays a high inter-individual variability. In WS of some of the patients, concentrations may be sub-therapeutic. However, the relevance of sub-therapeutic concentrations is unknown as no correlation has been established between concentration data and clinical outcome. Nevertheless, in the absence of clinical outcome studies, our data do not support the use of echinocandins at standard doses for the treatment of fungal wound infections, but underline the pivotal role of surgical debridement.
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Authors | Tiziana Gasperetti, René Welte, Herbert Oberacher, Jana Marx, Ingo Lorenz, Peter Schellongowski, Thomas Staudinger, Karin Burgmann, Philipp Eller, Tobias Santner, Andrea Griesmacher, Hartwig Pfisterer, Stephan Eschertzhuber, Maria Aigner, Michael Joannidis, Romuald Bellmann |
Journal | Infection
(Infection)
Vol. 49
Issue 4
Pg. 747-755
(Aug 2021)
ISSN: 1439-0973 [Electronic] Germany |
PMID | 33877638
(Publication Type: Journal Article)
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Copyright | © 2021. The Author(s). |
Chemical References |
- Antifungal Agents
- Echinocandins
- Lipopeptides
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Topics |
- Adult
- Antifungal Agents
(therapeutic use)
- Candidiasis, Invasive
(drug therapy)
- Critical Illness
- Echinocandins
- Humans
- Lipopeptides
- Microbial Sensitivity Tests
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