Beneficial Effects of Plant-Derived Natural Products on Non-alcoholic Fatty Liver Disease.

Abstract

Non-alcoholic fatty liver disease is becoming in one of the most prevalent liver diseases that leads to liver transplantation. This health problem is a multisystem disease with a complex pathogenesis that involves liver, adipose tissue, gut, and muscle. Although several pharmacological agents have been investigated to prevent or treat non-alcoholic fatty liver disease, currently there is no effective treatment for the management of this chronic liver disease. Nonetheless, the use of natural products has emerged as a alternative therapeutic for the treatment of hepatic diseases, including non-alcoholic fatty liver disease, due to its anti-inflammatory, antioxidant, antidiabetic, insulin-sensitizing, antiobesity, hypolipidemic, and hepatoprotective properties. In the present review, we have discussed the evidence from experimental and clinical studies regarding the potential beneficial effects of plant-derived natural products (quercetin, resveratrol, berberine, pomegranate, curcumin, cinnamon, green tea, coffee, garlic, ginger, ginseng, and gingko biloba) for the treatment or prevention of non-alcoholic fatty liver disease.

• Authors: Luis E Simental-Mendía, Claudia I Gamboa-Gómez, Fernando Guerrero-Romero, Mario Simental-Mendía, Adriana Sánchez-García, Mariana Rodríguez-Ramírez
• Journal: Advances in experimental medicine and biology (Adv Exp Med Biol) Vol. 1308 Pg. 257-272 ( 2021) ISSN: 0065-2598 [Print] United States
• PMID: 33861449 (Publication Type: Journal Article, Review)

Chemical References

• Antioxidants
• Biological Products
• Resveratrol

Topics

• Antioxidants (therapeutic use)
• Biological Products (therapeutic use)
• Humans
• Liver
• Non-alcoholic Fatty Liver Disease (drug therapy)
• Resveratrol