Comparison of Alternative Lipid Emulsions on Morbidities in Very-Low-Birth-Weight Preterms.

Abstract

OBJECTIVE:

To compare clinical outcomes of using different alternative lipid emulsions for longer durations in babies who are at high risk for preterm morbidities.

METHODS:

Preterm infants born ≤ 30 wk receiving SMOFlipid versus Clinoleic with longer durations (≥ 14 d) were included in this retrospective study. The authors compared demographic features, clinical applications, and morbidities between epochs: epoch 1 (Clinoleic, July 2017-June 2018) versus epoch 2 (SMOFlipid, July 2018-June 2019).

RESULTS:

A total of 91 infants were included in the study. In bivariate analysis; moderate bronchopulmonary dysplasia (BPD) (p = 0.000) and composite outcome [BPD, retinopathy of prematurity (ROP) needed treatment, cholestasis and late-onset sepsis and/or mortality] rates were significantly higher (p = 0.043) in Clinoleic group. In multivariate logistic regression analysis, it was found that the type of lipid emulsion used had no significant effect on these morbidities.

CONCLUSIONS:

Since both groups had comparable morbidity and mortality, both lipid emulsions are equally safe in preterm babies requiring parenteral nutrition.

• Authors: Adil Umut Zübarioğlu, Mesut Dursun
• Journal: Indian journal of pediatrics (Indian J Pediatr) Vol. 88 Issue 9 Pg. 905-911 (Sep 2021) ISSN: 0973-7693 [Electronic] India
• PMID: 33860883 (Publication Type: Journal Article)
• Copyright: © 2021. Dr. K C Chaudhuri Foundation.

Chemical References

• Emulsions
• Fish Oils
• Olive Oil
• Triglycerides
• Soybean Oil
• SMOFlipid

Topics

• Emulsions
• Fish Oils
• Humans
• Infant
• Infant, Newborn
• Infant, Premature
• Infant, Very Low Birth Weight
• Morbidity
• Olive Oil
• Retrospective Studies
• Soybean Oil
• Triglycerides