2-Oxaspiro[4.5]decane and α-pyrenocine derivatives from the endophytic fungus Roussoella sp. PSU-H51.

Abstract

One new 2-oxaspiro[4.5]decane, roussoellide, and one new α-pyrenocine, 2',3'-dihydropyrenocine A, together with nine known compounds including known arthropsolide A, and pyrenocines A and E, were obtained from the culture broth of the endophytic fungus Roussoella sp. Their structures were determined using spectroscopic data. The absolute configuration of known arthropsolide A was assigned on the basis of X-ray diffraction data using Cu Kα radiation. Known pyrenocine A displayed weak cytotoxic activity against breast cancer (MCF-7) cells with an IC50 value of 27.1 µM and weak antifungal activity against Microsporum gypseum SH-MU-4 with an MIC value of 615.2 µM.[Formula: see text].

• Authors: Ubonta Sommart, Vatcharin Rukachaisirikul, Saowanit Saithong, Souwalak Phongpaichit, Jariya Sakayaroj, Sita Preedanon, Kittipong Chainok, Teerayut Khunrong
• Journal: Natural product research (Nat Prod Res) Vol. 36 Issue 19 Pg. 4911-4920 (Oct 2022) ISSN: 1478-6427 [Electronic] England
• PMID: 33853446 (Publication Type: Journal Article)

Chemical References

• Alkanes
• Antifungal Agents
• Spiro Compounds
• arthropsolide a
• decane

Topics

• Alkanes
• Antifungal Agents (chemistry, pharmacology)
• Ascomycota (chemistry)
• Molecular Structure
• Spiro Compounds