Some case reports described
nephrotic syndrome (NS) associated with administering various
vaccines in two last decades. They report only 1 year follow-up. We want to summarize the 17-year clinical follow-up of the patient who had been reported in 2000 because of developing NS after
hepatitis B vaccination. Our patient first suffered from NS following
hepatitis B vaccination in 4 years old. He had been treated with standard
prednisolone regimen resulting
in complete remission. After the first diagnosis, he had three relapses in following years. Each relapse developed after Salk, pneumococcal, and
flu vaccines, respectively. Relapses had been easily controlled by
prednisolone. He had seven relapses until 14 years of age. Fortunately, no relapse has been observed between 2009 and 2016. Although he has been taking
alendronate and
Vitamin-D for
osteoporosis, he is a healthy young adult now. We think that some
vaccines may induce relapses in NS, as a triggering factor without being the primarily responsible factors.