Isolation, chemistry, and biology of pyrrolo[1,4]benzodiazepine natural products.

Abstract

The isolation of the antitumor antibiotic anthramycin in the 1960s prompted extensive research into pyrrolo[1,4]benzodiazepines (PBD) as potential therapeutics for the treatment of cancers. Since then, nearly 60 PBD natural products have been isolated and evaluated with regard to their biological activity. Synthetic studies and total syntheses have enabled access to PBD analogues, culminating in the development of highly potent anticancer agents. This review provides a summary of the occurrence and biological activity of PBD natural products and covers the strategies employed for their total syntheses.

• Authors: Guna Sakaine, Anastasija Ture, Julia Pedroni, Gints Smits
• Journal: Medicinal research reviews (Med Res Rev) Vol. 42 Issue 1 Pg. 5-55 (01 2022) ISSN: 1098-1128 [Electronic] United States
• PMID: 33846985 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)
• Copyright: © 2021 Wiley Periodicals LLC.

Chemical References

• Antineoplastic Agents
• Biological Products
• Pyrroles
• Anthramycin
• Benzodiazepines

Topics

• Anthramycin
• Antineoplastic Agents (pharmacology, therapeutic use)
• Benzodiazepines (pharmacology, therapeutic use)
• Biological Products (pharmacology)
• Biology
• Humans
• Pyrroles (pharmacology)