A fatal wound complication following sequential anti-angiogenesis, immune checkpoint inhibition and ultra-hypofractionated radiotherapy.

Abstract

PURPOSE:

Multimodality treatments combining radiotherapy, immune therapy and/or targeted therapy are under heavy investigation. Promising data from clinical trials are emerging, nevertheless unexpected interactions and adverse events should not be overlooked.

CASE PRESENTATION:

Here we present a case study of a patient with metastatic colon adenocarcinoma treated sequentially with a chemotherapy/targeted therapy combination, immune checkpoint inhibitors and ultra-hypofractionated radiotherapy. After radiation treatment, the patient developed extensive posterior abdominal wall wounds coinciding with regression of the irradiated metastatic tumour mass and marked elevation of the inflammation parameters.

CONCLUSION:

This case represents an unusual fatal wound complication after palliative ultra-hypofractionated radiotherapy. Further research into synergistic effects of sequential radiotherapy and anti-angiogenesis therapy may provide an advantage in anticipating severe sequelae.

• Authors: Miha Orazem, Cédric Draulans, Mathieu Spaas, Eric Van Cutsem, Marina Debecker, Gert De Meerleer, Sabine Tejpar, Jeroen Dekervel, Karin Haustermans
• Journal: Clinical journal of gastroenterology (Clin J Gastroenterol) Vol. 14 Issue 4 Pg. 1121-1125 (Aug 2021) ISSN: 1865-7265 [Electronic] Japan
• PMID: 33844128 (Publication Type: Case Reports, Journal Article)
• Copyright: © 2021. Japanese Society of Gastroenterology.

Chemical References

• Immune Checkpoint Inhibitors

Topics

• Combined Modality Therapy
• Humans
• Immune Checkpoint Inhibitors
• Immunotherapy