Abstract | OBJECTIVE: To explore the anti-hypoxic effects of oat oligopeptides (OOPs) in mice. METHODS: We randomly divided mice into six groups, including a vehicle control group, a whey protein group (0.50 g/kg), and four OOPs-treated groups (0.25, 0.50, 1.00, and 2.00 g/kg). The test substances were administered by gavage once a day for 30 days. The normobaric hypoxia, sodium nitrite toxicosis, and acute cerebral ischemia survival times were recorded. Also, the MDA content, the lactate levels, the LDH activity, and the mRNA levels of HIF-1α and VEGF in the brains were measured. We performed a whole blood cell analysis using a blood analyzer. RESULTS: CONCLUSION: OOPs have anti-hypoxic effects, and the mechanism may involve improving the blood's oxygen carrying capacity and oxygen utilization rate minimizing the lipid peroxidation lesions, increasing the brain's ability to buffer against lactic acidosis in mice, and promoting angiogenesis and regulating the hypoxic response.
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Authors | Di Li, Jinwei Ren, Qian Du, Peng Liu, Yong Li |
Journal | American journal of translational research
(Am J Transl Res)
Vol. 13
Issue 3
Pg. 1657-1666
( 2021)
ISSN: 1943-8141 [Print] United States |
PMID | 33841687
(Publication Type: Journal Article)
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Copyright | AJTR Copyright © 2021. |