Abstract |
In an effort to synthesize a library of bioactive molecules, we present an efficient synthesis of fused- thiazole derivatives of natural products and approved drugs by using an environmentally usable solvent, acetic acid, and without any external reagent. Cholestenone, ethisterone, progesterone, and nootkatone-derived epoxyketones have been utilized to synthesize 50 novel compounds. The plausible mechanism of the reaction has been determined by theoretical calculation using M06-2X/6-31+G(d,p). These novel molecules have been tested against cancer cell lines and pathogenic bacterial strains. Several ethisterone-based fused- thiazole compounds are found to be potent growth inhibitors of cancer cell lines at submicromolar concentrations.
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Authors | Rawan Alnufaie, Mohamad Akbar Ali, Ibrahim S Alkhaibari, Subrata Roy, Victor W Day, Mohammad A Alam |
Journal | New journal of chemistry = Nouveau journal de chimie
(New J Chem)
Vol. 45
Issue 13
Pg. 6001-6017
(Apr 07 2021)
ISSN: 1144-0546 [Print] England |
PMID | 33840994
(Publication Type: Journal Article)
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