Abstract | OBJECTIVES:
Acinar cell carcinoma of the pancreas (pACC) forms a rare subgroup of pancreatic tumors. We report on our institutional experience with systemic first- and further-line therapy in patients with metastatic pACC and embed our findings in a review of the literature. METHODS: Patients with stage IV pACC who started systemic treatment between 2008 and 2019 at our institution were identified via our institutional database. Clinical data were extracted from the patients' electronic data records. Survival times were calculated by the Kaplan-Meier method. RESULTS: Six patients received a fluoropyrimidine- and oxaliplatin-containing first-line treatment, and 4 patients were started on gemcitabine-based protocols. Median progression-free survival was 4.8 months [95% confidence interval (CI), 3.3 to not available (n.a.)], and median overall survival was 15.3 months (95% CI, 10.1 to n.a.). Residual survival for second-line treatment was 2.1 months (95% CI, 1.3 to n.a.), although 1 patient experienced almost complete remission under targeted therapy. CONCLUSIONS:
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Authors | Elena Busch, Wiebke Werft, Nina Bougatf, Thilo Hackert, Dirk Jäger, Christoph Springfeld, Anne Katrin Berger |
Journal | Pancreas
(Pancreas)
Vol. 50
Issue 3
Pg. 300-305
(03 01 2021)
ISSN: 1536-4828 [Electronic] United States |
PMID | 33835959
(Publication Type: Journal Article, Review)
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Copyright | Copyright © 2021 Wolters Kluwer Health, Inc. All rights reserved. |
Chemical References |
- Oxaliplatin
- Deoxycytidine
- Irinotecan
- Leucovorin
- Fluorouracil
- Gemcitabine
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Topics |
- Adult
- Aged
- Antineoplastic Combined Chemotherapy Protocols
(therapeutic use)
- Carcinoma, Acinar Cell
(drug therapy, pathology)
- Deoxycytidine
(administration & dosage, analogs & derivatives)
- Female
- Fluorouracil
(administration & dosage)
- Humans
- Irinotecan
(administration & dosage)
- Kaplan-Meier Estimate
- Leucovorin
(administration & dosage)
- Male
- Middle Aged
- Neoplasm Metastasis
- Oxaliplatin
(administration & dosage)
- Pancreas
(drug effects, pathology)
- Pancreatic Neoplasms
(drug therapy, pathology)
- Retrospective Studies
- Gemcitabine
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