Abstract | BACKGROUND: METHODS: Randomized controlled trials (RCTs) published in English and Chinese were retrieved by searching in the databases in October 2019, including PubMed, Cochrane Library, EMBASE, Sinomed, CNKI, VIP, and WanFang databases. Quantitative analyses and quality assessments were then conducted based on abstracted data. This study protocol is registered PROSPERO, number CRD42018095660. RESULTS: A total of 26 eligible RCTs involving 2,389 patients were included in our analysis. Overall, we observed an effect of increasing menstrual blood volumes owing to using TCM treatments plus bio-medicine (BM) (n=649; MD, 12.05; 95% CI: 5.23 to 18.87; P<0.00001; I2=96%). Besides, TCM combined with BM yielded a significant prolongation in menstrual periods (MD, 1.20; 95% CI: 0.78 to 1.62; P<0.00001; I2=76%), and had potential improvements on enhancing effectiveness rates, increasing endometrial thickness, and raising the levels of estradiol (E2) and progesterone (P). Concerning adverse events (AEs), no significant difference was found in either group. The quality of evidence was relatively low. CONCLUSIONS: This study seems to support the potential effect of TCM on treating oligomenorrhea. However, the relatively low quality of prior studies calls for future RCTs to further assess the efficacy of TCM on treating oligomenorrhea using rigorous designs.
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Authors | Yannan Li, Guozhen Zhao, Wei Shi, Yin Zhang, Hanlin Diao, Nan Ding, Panpan Li, Fang Zhang, Lei Yang, Mengyao Sun, Hang Yu, Bo Li, Li Xu |
Journal | Annals of palliative medicine
(Ann Palliat Med)
Vol. 10
Issue 12
Pg. 12955-12968
(Dec 2021)
ISSN: 2224-5839 [Electronic] China |
PMID | 33832303
(Publication Type: Journal Article, Meta-Analysis, Systematic Review)
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Topics |
- Female
- Humans
- Medicine, Chinese Traditional
- Oligomenorrhea
- Quality of Life
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