ADAMTS9-AS2: A Functional Long Non-coding RNA in Tumorigenesis.

Abstract

BACKGROUND:

Long non-coding RNAs (lncRNA) have been identified as novel molecular regulators in cancers. LncRNA ADAMTS9-AS2 can mediate the occurrence and development of cancer through various ways, such as regulating miRNAs, activating the classical signaling pathways in cancer, and so on, which have been studied by many scholars. In this review, we summarize the molecular mechanisms of ADAMTS9-AS2 in different human cancers.

METHODS:

Through a systematic search of PubMed, lncRNA ADAMTS9-AS2 mediated molecular mechanisms in cancer are summarized inductively.

RESULTS:

ADAMTS9-AS2 aberrantly expression in different cancers is closely related to cancer proliferation, invasion, migration, and inhibition of apoptosis. The involvement of ADAMTS9-AS2 in DNA methylation, mediating PI3K / Akt / mTOR signaling pathways, and regulating miRNAs and proteins, shows its significant potential as a therapeutic cancer target.

CONCLUSION:

LncRNA ADAMTS9-AS2 can become a promising biomolecular marker and a therapeutic target for human cancer.

• Authors: Wen Xu, Bei Wang, Yuxuan Cai, Jinlan Chen, Xing Lv, Chong Guo, Chengfu Yuan
• Journal: Current pharmaceutical design (Curr Pharm Des) 2021 Vol. 27 Issue 23 Pg. 2722-2727 ISSN: 1873-4286 [Electronic] United Arab Emirates
• PMID: 33823762 (Publication Type: Journal Article, Review)
• Copyright: Copyright© Bentham Science Publishers; For any queries, please email at [email protected].

Chemical References

• MicroRNAs
• RNA, Long Noncoding
• ADAMTS9 Protein
• ADAMTS9 protein, human

Topics

• ADAMTS9 Protein (genetics)
• Cell Line, Tumor
• Cell Movement
• Cell Proliferation (genetics)
• Cell Transformation, Neoplastic
• Gene Expression Regulation, Neoplastic
• Humans
• MicroRNAs (genetics)
• RNA, Long Noncoding (genetics)