Post-operative small pelvic intensity-modulated radiation therapy for early-stage cervical cancer with intermediate-risk factors: efficacy and toxicity.

Abstract

OBJECTIVE:

The aim of the present study was to retrospectively evaluate the toxicity and efficacy of post-operative small pelvic intensity-modulated radiotherapy in early-stage cervical cancer patients with intermediate-risk factors.

METHODS:

Between 2012 and 2016, 151 patients who had cervical cancer (International Federation of Gynecology and Obstetrics stage I-IIA) with intermediate-risk factors were treated with post-operative small pelvic intensity-modulated radiotherapy. The median dose of 50.4 Gy in 28 fractions with small pelvic intensity-modulated radiotherapy was prescribed to the planning target volume. The intensity-modulated radiotherapy technique used was conventional fixed-field intensity-modulated radiotherapy or helical tomotherapy.

RESULTS:

The median follow-up was 37 months. The 3-year disease-free survival and overall survival rates were 89 and 96%, respectively. A total of 144 patients (95.3%) were alive at the last follow-up. In total, 6 patients (3.9%) had recurrence: locoregional recurrence in 3 patients (2%), distant metastasis in 2 (1.3%), and both in 1 (0.6%). Diarrhoea was the most common acute toxicity. There were no patients suffering from acute or late grade ≥ 3 toxicity. Only 4 patients (2.6%) had late grade 2 toxicities.

CONCLUSIONS:

For early-stage cervical cancer patients with intermediate-risk factors, post-operative small pelvic intensity-modulated radiotherapy was safe and well tolerated. The rates of acute and late toxicities were quite satisfactory.

• Authors: Guangyu Zhang, Fangfang He, Li Miao, Haijian Wu, Youzhong Zhang, Chunli Fu
• Journal: Japanese journal of clinical oncology (Jpn J Clin Oncol) Vol. 51 Issue 6 Pg. 905-910 (May 28 2021) ISSN: 1465-3621 [Electronic] England
• PMID: 33822980 (Publication Type: Journal Article)
• Copyright: © The Author(s) 2021. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: [email protected].

Topics

• Adult
• Aged
• Carcinoma, Squamous Cell (mortality, pathology, radiotherapy, surgery)
• China (epidemiology)
• Disease-Free Survival
• Female
• Humans
• Middle Aged
• Neoplasm Recurrence, Local
• Neoplasm Staging
• Pelvis (pathology, radiation effects, surgery)
• Postoperative Period
• Radiotherapy, Adjuvant (adverse effects, methods)
• Radiotherapy, Intensity-Modulated (adverse effects, methods)
• Retrospective Studies
• Survival Analysis
• Treatment Outcome
• Tumor Burden (radiation effects)
• Uterine Cervical Neoplasms (mortality, pathology, radiotherapy, surgery)
• Young Adult