Abstract | OBJECTIVE: METHODS: Sera from chronic inflammatory demyelinating polyneuropathy ( CIDP) and myositis patients were analyzed, drawn pre-treatment and 6-12 weeks after the start of IVIg. In patients with apparent seroconversion, follow-up samples after treatment withdrawal were analyzed, if available. Patients treated with corticosteroids were included as controls. A two-tier protocol was used for serological testing consisting of the C6 Lyme ELISA (Oxford Immunotec) and confirmation by immunoglobulin M ( IgM) and immunoglobulin G ( IgG) immunoblot (Mikrogen® ). RESULTS: We included 61 patients: 51 patients were treated with IVIg and 10 with dexamethasone. Of the patients treated with IVIg, 42 had CIDP (82%) and were treated with Nanogam® (Sanquin Plasma Products). Nine patients had myositis (18%) and were treated with Privigen® (CSL Behring). Anti-Bbsl IgG seroprevalence pre-treatment was 3% (2/61). Apparent seroconversion during IVIg treatment occurred in 39% (20/51) of patients, all treated with Nanogam. Post-treatment seroreversion occurred in 92% (12/13) of patients with available follow-up samples; in 78% (7/9) seroreversion was observed within 3 months. CONCLUSIONS: Transient presence of anti-Bbsl IgG antibodies after IVIg is regularly observed. This effect appears to be dependent on the IVIg brand, probably reflecting variation in Bbsl exposure of plasma donors. Lyme borreliosis serological testing during, and weeks to months after, IVIg is therefore of limited utility.
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Authors | Ilse M Lucke, Amber Vrijlandt, Johan Lim, Anneke J van der Kooi, Ivo N van Schaik, Hans L Zaaijer, Joppe W Hovius, Filip Eftimov |
Journal | European journal of neurology
(Eur J Neurol)
Vol. 28
Issue 7
Pg. 2383-2387
(07 2021)
ISSN: 1468-1331 [Electronic] England |
PMID | 33817927
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | © 2021 The Authors. European Journal of Neurology published by John Wiley & Sons Ltd on behalf of European Academy of Neurology. |
Chemical References |
- Antibodies, Bacterial
- Immunoglobulin M
- Immunoglobulins, Intravenous
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Topics |
- Antibodies, Bacterial
- Borrelia burgdorferi
- Borrelia burgdorferi Group
- Cohort Studies
- Humans
- Immunoglobulin M
- Immunoglobulins, Intravenous
- Seroconversion
- Seroepidemiologic Studies
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