Prostate cancer is one of the leading causes of death despite an astoundingly high survival rate for localized
tumors. Though
prostate specific antigen (PSA) test, performed in conjunction with digital rectal examinations, is reasonably accurate, there are major caveats requiring a thorough assessment of risks and benefits prior to conducting the test.
MicroRNAs, a class of small non-coding RNAs, are stable molecules that can be detected in circulation by non-invasive methods and have gained importance in
cancer prognosis and diagnosis in the recent years. Here, we investigate circulating miR-940, a
miRNA known to play a role in
prostate cancer progression, in both cell culture supernatants as well as patient serum and urine samples to determine the utility of miR-940 as a new molecular marker for
prostate cancer detection. We found that miR-940 was significantly higher in serum from
cancer patients, specifically those with clinically significant
tumors (GS ≥ 7). Analysis of receiver operating characteristic curve demonstrated that miR-940 in combination with PSA had a higher area under curve value (AUC: 0.818) than the miR-940 alone (AUC: 0.75) for the diagnosis of
prostate cancer. This study provides promising results suggesting the use of miR-940 for
prostate cancer diagnosis.