[Bismuth subsalicylate treatment in chronic Campylobacter pylori-associated erosive gastritis].

Abstract

In a prospective open study 21 patients with upper abdominal complaints and chronic active gastritis as well as endoscopically proven erosions were treated with bismuth subsalicylate (4 X 30 ml/day, corresponding to 4 X 314 mg Bi3+) for three weeks. In 20 patients (95%) Campylobacter pylori (CP) was found in at least two of three examinations (culture, CLO quick-test, special histology). After the treatment 17 of 21 patients (81%) were CP negative, and the clinical symptoms had gradually disappeared. The histologically demonstrated degree of activity had regressed significantly after the three-week treatment; in 90% of patients the inflammatory process had completely abated. These results demonstrate that bismuth subsalicylate is highly effective in the acute treatment of CP-associated chronic erosive gastritis.

• Authors: P Malfertheiner, A Stanescu, K Baczako, E Vanek, G Bode, H Ditschuneit
• Journal: Deutsche medizinische Wochenschrift (1946) (Dtsch Med Wochenschr) Vol. 113 Issue 23 Pg. 923-9 (Jun 10 1988) ISSN: 0012-0472 [Print] Germany
• Vernacular Title: Wismutsubsalicylat-Behandlung bei Campylobacter-pylori-assoziierter chronischer erosiver Gastritis.
• PMID: 3378501 (Publication Type: English Abstract, Journal Article)

Chemical References

• Organometallic Compounds
• Salicylates
• bismuth subsalicylate
• Bismuth

Topics

• Adult
• Aged
• Biopsy
• Bismuth (blood, therapeutic use)
• Campylobacter (isolation & purification)
• Campylobacter Infections (drug therapy, microbiology, pathology)
• Chronic Disease
• Drug Evaluation
• Female
• Gastric Mucosa (microbiology, pathology)
• Gastritis (drug therapy, microbiology, pathology)
• Gastroscopy
• Humans
• Male
• Microscopy, Electron
• Microscopy, Electron, Scanning
• Middle Aged
• Organometallic Compounds (blood, therapeutic use)
• Salicylates (blood, therapeutic use)