Effect of fluororotic acid on the sialylation of the chicken liver, hepatoma MC-29 and serum glycoconjugates.

Abstract

Fluororotic acid, an orotic acid analogue which interferes with the nucleotide and RNA biosynthesis, was tested to determine its effect on: a) 14C-glucosamine and 14C-N-acetylmannosamine incorporation into acid-soluble nucleotide-sugars and into b) glycoconjugates from chicken liver and hepatoma induced by the avian leukosis strain Mc-29. In vivo metabolism studies indicated that this agent alters the nucleotide biosynthesis in both tissues investigated and causes a decrease in the sialylation rate of liver, hepatoma and serum glycolipids and glycoproteins.

• Authors: S Ivanov, E Gavazova, M Antonova, H Chelibonova-Lorer
• Journal: Neoplasma (Neoplasma) Vol. 35 Issue 2 Pg. 145-51 ( 1988) ISSN: 0028-2685 [Print] Slovakia
• PMID: 3374705 (Publication Type: Journal Article)

Chemical References

• Carbon Radioisotopes
• Glycoconjugates
• Hexosamines
• Sialic Acids
• Orotic Acid
• 5-fluoroorotic acid
• Glucosamine
• N-acetylmannosamine

Topics

• Animals
• Carbon Radioisotopes
• Chickens
• Glucosamine (metabolism)
• Glycoconjugates (biosynthesis, blood)
• Hexosamines (metabolism)
• Liver (metabolism)
• Liver Neoplasms, Experimental (metabolism)
• Orotic Acid (analogs & derivatives, pharmacology)
• Sialic Acids (blood, metabolism)