Role of the HLA-G immune checkpoint molecule in pregnancy.

Abstract

The non-classical HLA class I molecule HLA-G is expressed in trophoblasts where it contributes to maternal-fetal tolerance. HLA-G has been implicated in the control of trophoblast invasion, uterine vascular remodeling, and maintenance of a local immunosuppressive state. Understanding HLA-G biology at the maternal-fetal interface is therefore a critical issue in reproduction. In this regard, we review here: (i) the effects of HLA-G on decidual leucocytes and stromal cells, (ii) the contribution of trogocytosis in HLA-G expression on decidual cells, (iii) its interaction with the ILT2, ILT4 and KIR2DL4 receptors, (iv) the link between HLA-G polymorphism and pregnancy disorders, and (v) the expression of newly-described HLA-G isoforms at the maternal-fetal interface.

• Authors: Nathalie Rouas-Freiss, Philippe Moreau, Joel LeMaoult, Bela Papp, Diana Tronik-Le Roux, Edgardo D Carosella
• Journal: Human immunology (Hum Immunol) Vol. 82 Issue 5 Pg. 353-361 (May 2021) ISSN: 1879-1166 [Electronic] United States
• PMID: 33745758 (Publication Type: Journal Article, Review)
• Copyright: Copyright © 2021. Published by Elsevier Inc.

Chemical References

• HLA-G Antigens

Topics

• Animals
• Decidua (immunology)
• Female
• Genetic Predisposition to Disease
• HLA-G Antigens (genetics, immunology)
• Humans
• Polymorphism, Genetic
• Pregnancy (immunology)
• Pregnancy Complications (genetics, immunology)
• Signal Transduction
• Trogocytosis
• Trophoblasts (immunology)