Abstract | INTRODUCTION: MATHERIALS AND METHODS: Seventy-nine consecutive patients with sudden worsening of respiratory failure were evaluated. All patients (71% male) had a confirmed SARS-CoV-2 infection and signs, symptoms and radiological findings compatible with COVID-19 pneumonia and all of them underwent a trial of NIV. Primary outcomes were NIV success and failure defined by intubation and mortality rate. Secondary outcome was the duration of NIV. RESULTS: NIV was successful in 38 (48.1%) patients (Table 1). EOT was necessary in 21 patients (26.6%). Death occurred in 20 patients (25.3%). In the group of patients having failed a trial with NIV and then being intubated, compared to those who continued NIV, there was no higher mortality rate. By evaluating the ICU survival outcome of the subgroup of patients intubated after NIV, 57% of the patients were discharged and 43% died. CONCLUSION: Previous studies conducted on patients undergoing invasive mechanical ventilation showed higher mortality rate than the present study. Our data showed that NIV can avoid intubation in almost half of the patients. Therefore, this data could reassure clinicians who would consider using NIV in COVID-19 ARDS-related treatment.
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Authors | Francesco Menzella, Chiara Barbieri, Matteo Fontana, Chiara Scelfo, Claudia Castagnetti, Giulia Ghidoni, Patrizia Ruggiero, Francesco Livrieri, Roberto Piro, Luca Ghidorsi, Gloria Montanari, Giorgia Gibellini, Eleonora Casalini, Francesco Falco, Chiara Catellani, Nicola Facciolongo |
Journal | The clinical respiratory journal
(Clin Respir J)
Vol. 15
Issue 7
Pg. 779-787
(Jul 2021)
ISSN: 1752-699X [Electronic] England |
PMID | 33728822
(Publication Type: Journal Article)
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Copyright | © 2021 John Wiley & Sons Ltd. |
Topics |
- COVID-19
- Female
- Humans
- Male
- Noninvasive Ventilation
- Pandemics
- Respiratory Distress Syndrome
(therapy)
- Respiratory Insufficiency
(therapy)
- SARS-CoV-2
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