Aim to determine the efficacy of
drug aminodihydrophthalazinedione
sodium (
Galavit) for prevention of progression of the
coronavirus infection pulmonary complications: acceleration of regression of pulmonary infiltrates and resolution of COVID-induced
pneumonia. 22 patients with medium and severe COVID-induced
pneumonia were included in the study. The study included 8 men and 14 women, the average age was 62.17.4 years. Patients with more than one adverse prognostic factor made 82%. Average volume of pulmonary tissue affection (computer tomography CT-2, 2550% of lung volume) was registered in 13 (59.1%) patients, significant volume (CT-3, 5075% of lung volume), in 9 (40.9%) patients. All patients had progressive
respiratory failure manifestations due to
hypoxemia and related diseases. Aminodihydrophthalazinedione
sodium was administered for 714 days from the beginning of disease, at the end of the course of standard complex
therapy, in case of preservation of signs of intoxication, negative dynamics according to computer tomography data. Administration of aminodihydrophthalazinedione
sodium had a positive effect on the dynamics of clinical scores. The progression of
respiratory failure was halted and there was an increase in SpO2 values. According to the control computer tomography data the stabilization of the pulmonary parenchyma affection degree was noted, as well as reduction of the size of the compacted areas in the pulmonary tissue and formation of the picture of organising
pneumonia that contributed to reduction of
respiratory failure grade. The use of aminodihydrophthalazinedione
sodium in complex
therapy of COVID-induced
pneumonia has a modulating effect on the immune system, prevents the progression of pulmonary tissue affection, promotes regression of infiltration foci, preventing the development of excessive pneumofibrosis and the progression of
respiratory failure.