Family
hypercholesterolemia (HSX) is a form of genetically deterministic increase in blood
lipid levels associated with a high risk of
cardiovascular disease, usually at a young age. HSX is a common
genetic disease found in the general population in most countries in 1:500 people. Clinically xantomas are found in achilles
tendor and wrist flexors, lipoid
arc of the cornea, concentration of total
cholesterol and
low-density lipoproteins is 4.911.6 mmol/l.
Gilberts syndrome is a hereditary benign hyperbilirubinium, associated with a decrease in the functional activity of the liver
enzyme uridinfosfat-glucuronosil
transferase. Clinically, this syndrome appers in intermittent
jaundice, which is provoked by physical activity, consumption of alcoholic beverages, insulation and an increase in the level of indirect
bilirubin within 20100 micromol/ml. The article presents a rare clinical case of genetic combination of HSC SSC and
Gilbert syndrome a young patient has and discusses the elevated
bilirubin levels protective role in the
atherosclerosis progression in
Gilbert syndrome.