Novel formulations and drug delivery systems to administer biological solids.

Abstract

Recent advances in formulation sciences have expanded the previously limited design space for biological modalities, including peptide, protein, and vaccine products. At the same time, the discovery and application of new modalities, such as cellular therapies and gene therapies, have presented formidable challenges to formulation scientists. We explore these challenges and highlight the opportunities to overcome them through the development of novel formulations and drug delivery systems as biological solids. We review the current progress in both industry and academic laboratories, and we provide expert perspectives in those settings. Formulation scientists have made a tremendous effort to accommodate the needs of these novel delivery routes. These include stability-preserving formulations and dehydration processes as well as dosing regimes and dosage forms that improve patient compliance.

• Authors: Yajie Zhang, Daniel A Davis, Khaled AboulFotouh, Jieliang Wang, Donna Williams, Akhilesh Bhambhani, Michael Zakrewsky, Mohammed Maniruzzaman, Zhengrong Cui, Robert O Williams 3rd
• Journal: Advanced drug delivery reviews (Adv Drug Deliv Rev) Vol. 172 Pg. 183-210 (05 2021) ISSN: 1872-8294 [Electronic] Netherlands
• PMID: 33705873 (Publication Type: Journal Article, Review)
• Copyright: Copyright © 2021 Elsevier B.V. All rights reserved.

Chemical References

• Biological Products
• Peptides
• Proteins
• Vaccines

Topics

• Animals
• Biological Products (administration & dosage, chemistry)
• Chemistry, Pharmaceutical (methods)
• Drug Administration Schedule
• Drug Delivery Systems
• Drug Stability
• Humans
• Medication Adherence
• Peptides (administration & dosage, chemistry)
• Proteins (administration & dosage, chemistry)
• Vaccines (administration & dosage, chemistry)