Rosuvastatin for the prevention of venous thromboembolism: a pooled analysis of the HOPE-3 and JUPITER randomized controlled trials.

Abstract

AIMS:

To examine the association between rosuvastatin and VTE risk, and whether effects vary in different subpopulations stratified by key demographic, cardiovascular disease (CVD) risk factors, and other risk factors associated with VTE.

METHODS AND RESULTS:

An individual participant data meta-analysis was conducted across two randomized controlled trials in 30 507 participants over a mean follow-up of 3.62 years, individuals had no prior history of vascular disease but were at intermediate CV risk. In both trials, participants were randomized to receive rosuvastatin or matching placebo. The primary outcome was VTE during follow-up, defined as either deep vein thrombosis or pulmonary embolism. Associations between rosuvastatin and VTE were examined in the overall pooled cohort, and subpopulations stratified by demographic risk factors (i.e. age and sex), CVD risk factors (i.e. obesity, smoking, lipid levels, blood pressure levels, and C-reactive protein level), and a history of cancer. Mean age was 65.96 (SD 7.19) years of age, and 17 832 (58.45%) were male and 5434 (17.82%) were smokers, median BMI was 27.6 [interquartile range (IQR) 24.7-31.1] kg/m2, and median CRP level was 3.4 (IQR 2.1-6.0) mg/L. There were 139 VTE events. In the pooled cohort, rosuvastatin was associated with a large proportional reduction in the risk of VTE (hazard ratio 0.53, 95% CI 0.37-0.75). No significant interactions were observed between treatment with rosuvastatin and the risk of VTE across subpopulations stratified by demographic, CVD risk factors, or a history of cancer (P-values for interactions >0.05 for all subgroups).

CONCLUSION:

Rosuvastatin is associated with a 47% proportional reduction in the risk of VTE, and its effect is consistent both in the presence or absence of VTE-related clinical risk factors.

• Authors: Philip Joseph, Robert Glynn, Eva Lonn, Chinthanie Ramasundarahettige, John Eikelboom, Jean MacFadyen, Paul Ridker, Salim Yusuf
• Journal: Cardiovascular research (Cardiovasc Res) Vol. 118 Issue 3 Pg. 897-903 (02 21 2022) ISSN: 1755-3245 [Electronic] England
• PMID: 33705531 (Publication Type: Journal Article, Meta-Analysis, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)
• Copyright: Published on behalf of the European Society of Cardiology. All rights reserved. © The Author(s) 2021. For permissions, please email: [email protected].

Chemical References

• Hydroxymethylglutaryl-CoA Reductase Inhibitors
• Rosuvastatin Calcium

Topics

• Aged
• Humans
• Hydroxymethylglutaryl-CoA Reductase Inhibitors (adverse effects)
• Male
• Pulmonary Embolism
• Randomized Controlled Trials as Topic
• Risk Factors
• Rosuvastatin Calcium (adverse effects)
• Venous Thromboembolism (diagnosis, epidemiology, prevention & control)