Abstract | AIMS: Seizure outcome of autoimmune encephalitis (AE) varies from seizure-free to refractory epilepsy, and the associated factors remain unclear. We aimed to describe seizure characteristics, identify seizure outcome-related factors, and discuss the medication strategy of antiepileptic drugs (AEDs) at the first onset of AE. METHODS: We retrospectively studied the data of 86 patients with clinically diagnosed AE. The clinical characteristics were described using a chi-square test. Seizure outcome-related factors were assessed using multivariable logistic regression analysis. RESULTS: CONCLUSIONS: In the acute phase, seizure characteristics may be considered in the utilization of AEDs. For patients with seizure-free status in the acute phase, clinical manifestation (onset with seizure or not, whether status epilepticus occurs or not), therapy regimen (human gamma globulin administered or not), and antibody titer may be considered when formulating the strategy for withdrawal of AEDs post-acute phase.
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Authors | Yilin Wang, Xin Li, Pingping He, Jiangning Yin, Ruofei Dong, Yu Fu, Hong Zhang |
Journal | CNS neuroscience & therapeutics
(CNS Neurosci Ther)
Vol. 27
Issue 6
Pg. 694-701
(06 2021)
ISSN: 1755-5949 [Electronic] England |
PMID | 33683811
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | © 2021 The Authors. CNS Neuroscience & Therapeutics published by John Wiley & Sons Ltd. |
Chemical References |
- Anticonvulsants
- Receptors, GABA-A
- Receptors, N-Methyl-D-Aspartate
- gamma-Globulins
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Topics |
- Adolescent
- Adult
- Anticonvulsants
(therapeutic use)
- Autoimmune Diseases
(complications, drug therapy)
- Child
- Child, Preschool
- Encephalitis
(complications, drug therapy, immunology)
- Female
- Humans
- Immunotherapy
- Infant
- Infant, Newborn
- Male
- Receptors, GABA-A
(immunology)
- Receptors, N-Methyl-D-Aspartate
(immunology)
- Retrospective Studies
- Seizures
(drug therapy, etiology)
- Status Epilepticus
- Treatment Outcome
- gamma-Globulins
(therapeutic use)
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