Overcome the tumor immunotherapy resistance by combination of the HDAC6 inhibitors with antitumor immunomodulatory agents.

Abstract

Tumor immunotherapy is currently subject of intense scientific and clinical developments. In previous decade, therapists used natural immune system from the human body to treat several diseases. Although tumor immune disease is a big challenge, combinatorial therapeutic strategy has been succeeded to show the clinical significance. In this context, we discuss the HDAC6 and tumor immune diseases relationship. Also, we summarized the current state of knowledge that based on the combination treatments of the HDAC6 inhibitors (HDAC6is) with antitumor immunomodulatory agents. We observed that, the combination therapies slow down the tumor immune diseases by blocking the aggresome and proteasome pathway. The combination therapy was able to reduce M2 macrophage and increasing PD-L1 blockade sensitivity. Most importantly, multiple combinations of HDAC6is with other agents may consider as potential strategies to treat tumor immune diseases, by reducing the side effects and improve efficacy for the future clinical development.

• Authors: Mussa Yussuf Khamis, Hui-Pan Wu, Qin Ma, Yi-Han Li, Li-Ying Ma, Xin-Hui Zhang, Hong-Min Liu
• Journal: Bioorganic chemistry (Bioorg Chem) Vol. 109 Pg. 104754 (04 2021) ISSN: 1090-2120 [Electronic] United States
• PMID: 33677416 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)
• Copyright: Copyright © 2021 Elsevier Inc. All rights reserved.

Chemical References

• Antineoplastic Agents
• Histone Deacetylase Inhibitors
• Immunologic Factors
• HDAC6 protein, human
• Histone Deacetylase 6

Topics

• Antineoplastic Agents (chemical synthesis, chemistry, pharmacology)
• Cell Proliferation (drug effects)
• Histone Deacetylase 6 (antagonists & inhibitors, chemistry, immunology)
• Histone Deacetylase Inhibitors (chemical synthesis, chemistry, pharmacology)
• Humans
• Immunologic Factors (chemical synthesis, chemistry, pharmacology)
• Immunotherapy
• Molecular Structure
• Neoplasms (immunology, pathology, therapy)