Abstract | BACKGROUND: OBJECTIVE: To explore the levels of nine metals in plasma and the effect on cognitive function among in-service workers. METHODS: In this cross-sectional study, cognitive function was assessed using the Montreal Cognitive Assessment (MoCA), which included seven subitems: executive/visuospatial abilities; naming; attention and calculation; language; abstract; recall; and orientation. The plasma levels of nine kinds of metals were measured by inductively coupled plasma-mass spectrometry (ICP-MS). A multivariate generalized linear regression model and Bayesian kernel machine regression (BKMR) were selected to estimate the relationship between metal plasma level and MoCA scores with adjustment for confounders. RESULTS: One hundred and eighty-seven workers participated in this study. In the multivariable generalized linear model, among these nine metals studied, five were related to the MoCA score: aluminum, lithium, cobalt, zinc and chromium. In the BKMR model, a significantly negative correlation between the plasma aluminum, lithium and the total MoCA score was observed. Moreover, for subitems on the MoCA scale, the plasma levels of lithium, aluminum, and zinc had a significant correlation with the executive/visuospatial abilities, naming, and orientation abilities, respectively. The log-transformation concentrations of plasma aluminum and lithium were negatively correlated with the executive/visuospatial abilities and naming abilities, respectively. The log-transformation plasma zinc concentration was positively correlated with orientation abilities. CONCLUSION:
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Authors | Nan Shang, Lan Zhang, Shuo Wang, Tao Huang, Yanhong Wang, Xiaocheng Gao, Shimeng Xu, Jingqi Zhang, Ling Zhang, Qiao Niu, Qinli Zhang |
Journal | Ecotoxicology and environmental safety
(Ecotoxicol Environ Saf)
Vol. 214
Pg. 112110
(May 2021)
ISSN: 1090-2414 [Electronic] Netherlands |
PMID | 33677379
(Publication Type: Journal Article)
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Copyright | Copyright © 2021. Published by Elsevier Inc. |
Chemical References |
- Air Pollutants, Occupational
- Metals
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Topics |
- Adult
- Air Pollutants, Occupational
(blood)
- China
(epidemiology)
- Cognition
- Cognitive Dysfunction
(blood, epidemiology)
- Cross-Sectional Studies
- Gas Chromatography-Mass Spectrometry
- Humans
- Male
- Metallurgy
- Metals
(blood)
- Middle Aged
- Neuropsychological Tests
- Young Adult
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