New views on endothelial dysfunction in gestational hypertension and potential therapy targets.

Abstract

The placenta has vital roles in metabolite exchange, fetal growth, and pre-eclampsia (PE). In this review, we discuss the pathogenesis of hypertension in pregnancy, focusing on four major theories to explain PE, discussing endothelial roles in those theories. We focus in particular on the roles of nitric oxide (NO) and prostacyclin (PGI2) in placental endothelium, and propose new hypotheses for the influence and mechanisms of endothelial NO and PGI2 signaling pathways in PE.

• Authors: Xueqin Feng, Yanping Liu, Yingying Zhang, Yumeng Zhang, Huan Li, Qiutong Zheng, Na Li, Jiaqi Tang, Zhice Xu
• Journal: Drug discovery today (Drug Discov Today) Vol. 26 Issue 6 Pg. 1420-1436 (06 2021) ISSN: 1878-5832 [Electronic] England
• PMID: 33677145 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)
• Copyright: Copyright © 2021 Elsevier Ltd. All rights reserved.

Chemical References

• Nitric Oxide
• Epoprostenol

Topics

• Animals
• Endothelium, Vascular (pathology)
• Epoprostenol (metabolism)
• Female
• Humans
• Hypertension, Pregnancy-Induced (physiopathology)
• Nitric Oxide (metabolism)
• Placenta (blood supply)
• Pre-Eclampsia (physiopathology)
• Pregnancy
• Signal Transduction (physiology)