The prognostic value of serum albumin levels and respiratory rate for community-acquired pneumonia: A prospective, multi-center study.

Abstract

Community-acquired pneumonia (CAP) is a respiratory disease frequently requiring hospital admission, and a significant cause of death worldwide. This study aimed to investigate the prognostic value of clinical indicators. A prospective, multi-center study was conducted (January 2017-December 2018) where patient demographic and clinical data were recorded (N = 366). The 30-day mortality rate was 5.46%. Cox Regression analyses showed that serum albumin (ALB) and respiratory rate (RR) were independent prognostic variables for 30-day survival in patients with CAP. Albumin negatively correlated with the Pneumonia Severity Index (PSI) and CURB-65 scores using Pearson and Spearman tests. Survival curves showed that a RR >24 breaths/min or ALB ≤30 g/L were associated with a significantly higher risk of mortality. The area-under-the-curve (AUC) for predicting 30-day mortality in patients with CAP was 0.762, 0.763, 0.790, and 0.784 for ALB, RR, PSI, and CURB-65, respectively. The AUC for the prediction of 30-day mortality using ALB combined with PSI, CURB-65 scores, and RR was 0.822 (95% CI 0.731-0.912), 0.847 (95% CI 0.755-0.938), and 0.847 (95% CI 0.738-0.955), respectively. Albumin and RR were found to be reliable prognostic factors for CAP. This combination showed equal predictive value when compared to adding ALB assessment to PSI and CURB-65 scores, which could improve their prognostic accuracy.

• Authors: Lili Zhao, Jing Bao, Ying Shang, Ying Zhang, Lu Yin, Yan Yu, Yu Xie, Li Chen, Yali Zheng, Yu Xu, Zhancheng Gao
• Journal: PloS one (PLoS One) Vol. 16 Issue 3 Pg. e0248002 ( 2021) ISSN: 1932-6203 [Electronic] United States
• PMID: 33662036 (Publication Type: Clinical Trial, Journal Article, Multicenter Study, Observational Study, Research Support, Non-U.S. Gov't)

Chemical References

• Serum Albumin, Human

Topics

• Aged
• Area Under Curve
• Community-Acquired Infections (blood, diagnosis, physiopathology)
• Female
• Humans
• Male
• Middle Aged
• Prognosis
• Prospective Studies
• Respiratory Rate
• Serum Albumin, Human (analysis)
• Severity of Illness Index