Granulomatosis with polyangiitis presenting as pancreatic disease.

Abstract

Granulomatosis with polyangiitis (GPA) is a rare necrotising small vessel vasculitis typically associated with oronasal, pulmonary and renal manifestations. Pancreatic disease is an exceedingly rare initial presentation and is associated with delayed diagnosis and rapid progression. We discuss a 66-year-old woman presenting with epigastric pain, elevated lipase and radiographic evidence of focal pancreatitis. She had no relevant medical history and no lithiasis seen on imaging. Pertinent findings include strawberry gingivitis, positive proteinase-antineutrophil cytoplasm antibody (98% specificity) and focal nodular parenchymal lung lesions on CT chest-all of which are consistent with a diagnosis of GPA. She was promptly started on high-dose steroids which resulted in significant clinical and biochemical improvement. Cyclophosphamide was added once biopsy confirmed the absence of malignancy. In order to optimise the clinical outcomes of GPA, physicians must keep a wide differential and high index of suspicion in the setting of unexplained pancreatitis with systemic features.

• Authors: Jessie Jia Tao, Arnav Agarwal, Ari Benjamin Cuperfain, Christian Pagnoux
• Journal: BMJ case reports (BMJ Case Rep) Vol. 14 Issue 3 (Mar 02 2021) ISSN: 1757-790X [Electronic] England
• PMID: 33653864 (Publication Type: Case Reports, Journal Article)
• Copyright: © BMJ Publishing Group Limited 2021. No commercial re-use. See rights and permissions. Published by BMJ.

Chemical References

• Antibodies, Antineutrophil Cytoplasmic
• Cyclophosphamide

Topics

• Aged
• Antibodies, Antineutrophil Cytoplasmic (analysis)
• Biopsy
• Cyclophosphamide (therapeutic use)
• Female
• Granulomatosis with Polyangiitis (complications, diagnosis, drug therapy)
• Humans
• Pancreatic Diseases (diagnostic imaging, drug therapy)