Abstract | BACKGROUND: Owing to high genetic diversities of tumor cells and low response rate of standard chemotherapy, patients with triple negative breast cancer (TNBC) have short progression-free survivals and poor outcomes, which need to explore an effective approach to improve therapeutic efficacy. METHODS: RESULTS: The as-synthesized Dox@IR825@Gd@CDs displayed favorable MRI ability in vivo. Upon NIR laser irradiation, Dox@IR825@Gd@CDs could convert the NIR light to heat and efficiently inhibit tumor growth through photothermal chemotherapy in vitro and in vivo. Additionally, the impact of photothermal chemotherapy on the murine motor coordination was assessed by rotarod test. Dox@IR825@Gd@CDs presented low toxicity and high photothermal chemotherapy efficiency. CONCLUSION: A noble theranostic nanoplatform (Dox@IR825@Gd@CDs) was developed that could be tailored to achieve loading of Dox and IR825, intracellular delivery, favorable MRI, excellent combination therapy with photothermal therapy and chemotherapy to enhance therapeutic effect against TNBC cells. This study will provide a promising strategy for the development of Gd-based nanomaterials for MRI and combinational therapy for TNBC.
|
Authors | Qunjiao Jiang, Li Liu, Qiuying Li, Yi Cao, Dong Chen, Qishi Du, Xiaobo Yang, Dongping Huang, Renjun Pei, Xing Chen, Gang Huang |
Journal | Journal of nanobiotechnology
(J Nanobiotechnology)
Vol. 19
Issue 1
Pg. 64
(Mar 02 2021)
ISSN: 1477-3155 [Electronic] England |
PMID | 33653352
(Publication Type: Journal Article)
|
Chemical References |
- Drug Carriers
- Carbon
- Doxorubicin
- Gadolinium
- gadolinium chloride
|
Topics |
- Animals
- Carbon
(chemistry)
- Cell Line, Tumor
- Combined Modality Therapy
- Doxorubicin
- Drug Carriers
(chemistry)
- Drug Delivery Systems
(methods)
- Drug Therapy
(methods)
- Female
- Gadolinium
(chemistry)
- Humans
- Infrared Rays
- Lasers
- Magnetic Resonance Imaging
(methods)
- Mice
- Mice, Inbred BALB C
- Mice, Nude
- Nanoparticles
(chemistry)
- Nanostructures
(chemistry)
- Phototherapy
(methods)
- Triple Negative Breast Neoplasms
(drug therapy, radiotherapy)
- Xenograft Model Antitumor Assays
|