Different methods of enhancing the efficacy of topical tacrolimus in extra-facial vitiligo: A comparative study.

Abstract

BACKGROUND:

Vitiligo is an acquired pigmentation disorder due to loss of melanocytes. Topical tacrolimus is effective in vitiligo treatment with minimal effect on extra-facial lesions.

OBJECTIVE:

To assess different methods of enhancing the absorption of topical tacrolimus in extra-facial vitiligo sites using microneedling and occlusion.

METHODS:

This study included 20 adult patients of both sexes with non-segmental vitiligo. Four extra-facial vitiligo lesions in each patient were randomly labeled A, B, C, and D and treated as follows: area A: tacrolimus ointment (0.03%) application twice/day, area B: microneedling once/week and tacrolimus ointment application directly after microneedling and twice/day the rest of the week, area C: microneedling once/week alone, and area D: tacrolimus ointment application twice/day under occlusion by polyethylene foil. The evaluation was done clinically by calculating the re-pigmentation percent after 6 months of treatment.

RESULTS:

Responders in area B were 45%, and 35% in area C, and 25% in both areas A and D. No statistically significant difference was detected regarding the re-pigmentation percent between the four areas (p > 0.05). No correlations were detected between re-pigmentation percent and patients' data.

CONCLUSION:

Combination of microneedling and topical tacrolimus has an edge over monotherapy in vitiligo, and further studies are needed to verify such results.

• Authors: Samia M Esmat, Heba Ismail Gawdat, Rehab A Hegazy, Farah Sayed Ahmed, Eman Raafat Said
• Journal: Journal of cosmetic dermatology (J Cosmet Dermatol) Vol. 20 Issue 11 Pg. 3545-3551 (Nov 2021) ISSN: 1473-2165 [Electronic] England
• PMID: 33626213 (Publication Type: Journal Article, Randomized Controlled Trial)
• Copyright: © 2021 Wiley Periodicals LLC.

Chemical References

• Tacrolimus

Topics

• Adult
• Face
• Female
• Humans
• Male
• Pigmentation Disorders
• Tacrolimus
• Treatment Outcome
• Vitiligo (drug therapy)