Low-dose aspirin and the severity of ıschemic colitis: A single-center retrospective study.

Abstract

BACKGROUND/AIMS:

This retrospective study aimed to evaluate the effect of low-dose aspirin (50-150 mg/d) on the severity of ischemic colitis.

MATERIALS AND METHODS:

A total of 244 patients admitted to our hospital for ischemic colitis between 2013 and 2018 were included in the study. Patients were divided into two groups-aspirin and non-aspirin groups-based on their recent history of aspirin use before the onset of ischemic colitis. Clinical performance, biochemical indices, and endoscopic findings were compared.

RESULTS:

The average age and the proportion of underlying disease, including hypertension, cerebral infarction, and coronary heart disease in the aspirin group was significantly higher than those in the non-aspirin group (p<0.05). In terms of clinical symptoms, the proportion of diarrhea in the aspirin group was significantly higher than that in the non-aspirin group, while the proportion of abdominal pain was significantly lower in the aspirin group compared with the non-aspirin group. Colonoscopy results showed that the incidence of ulceration was significantly higher in the aspirin group than in the non-aspirin group (p<0.05).

CONCLUSION:

The use of low-dose aspirin may aggravate the severity and mask the symptoms of abdominal pain in ischemic colitis.

• Authors: Weiming Xiao, Shuai Yang Zhou, Keyan Wu, Bin Deng, Dacheng Wu, Yuanzhi Wang, Weijuan Gong, Yanbing Ding, Guotao Lu
• Journal: The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology (Turk J Gastroenterol) Vol. 31 Issue 12 Pg. 848-852 (12 2020) ISSN: 2148-5607 [Electronic] Turkey
• PMID: 33625996 (Publication Type: Evaluation Study, Journal Article)

Chemical References

• Anti-Inflammatory Agents, Non-Steroidal
• Aspirin

Topics

• Abdominal Pain (etiology, pathology)
• Aged
• Anti-Inflammatory Agents, Non-Steroidal (administration & dosage)
• Aspirin (administration & dosage)
• Colitis, Ischemic (complications, drug therapy)
• Colon (drug effects, pathology)
• Colonic Diseases (etiology, pathology)
• Female
• Humans
• Male
• Middle Aged
• Retrospective Studies
• Severity of Illness Index
• Treatment Outcome
• Ulcer (etiology, pathology)