Abstract | BACKGROUND: AIMS: MATERIALS AND METHODS: To assess the concentration of gelsolin and S1P, immunoblotting and HPLC technique were employed, respectively. Additionally, the concentrations of amylase, lipase, C-reactive protein (CRP), procalcitonin (PCT) and the number of white blood cells (WBC) and platelet (PLT) were recorded. RESULTS: We found that both pGSN and S1P concentrations in the plasma of the AP patients were significantly lower (pGSN ~ 15-165 mg/L; S1P ~ 100-360 pmol/mL) when compared to the levels of pGSN and S1P in a control group (pGSN ~ 130-240 mg/L; S1P ~ 260-400 pmol/mL). Additionally, higher concentrations of CRP, WBC, amylase and lipase were associated with low level of gelsolin in the blood of AP patients. No correlations between the level of PCT and PLT with gelsolin concentration were noticed. CONCLUSION: Plasma gelsolin and S1P levels decrease during severe acute pancreatitis. Simultaneous assessment of pGSN and S1P can be useful in development of more accurate diagnostic strategies for patients with severe acute pancreatitis.
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Authors | Tomasz Wollny, Marzena Wątek, Urszula Wnorowska, Ewelina Piktel, Stanisław Góźdź, Krzysztof Kurek, Przemysław Wolak, Grzegorz Król, Małgorzata Żendzian-Piotrowska, Robert Bucki |
Journal | Digestive diseases and sciences
(Dig Dis Sci)
Vol. 67
Issue 2
Pg. 536-545
(02 2022)
ISSN: 1573-2568 [Electronic] United States |
PMID | 33620599
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | © 2021. The Author(s). |
Chemical References |
- Gelsolin
- Lysophospholipids
- Procalcitonin
- sphingosine 1-phosphate
- C-Reactive Protein
- Lipase
- Amylases
- Sphingosine
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Topics |
- Adult
- Aged
- Amylases
(blood)
- C-Reactive Protein
(metabolism)
- Chromatography, High Pressure Liquid
- Female
- Gelsolin
(blood)
- Humans
- Leukocyte Count
- Lipase
(blood)
- Lysophospholipids
(blood)
- Male
- Middle Aged
- Pancreatitis
(blood)
- Platelet Count
- Procalcitonin
(blood)
- Severity of Illness Index
- Sphingosine
(analogs & derivatives, blood)
- Young Adult
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