Abstract | INTRODUCTION: AREAS COVERED:
Emicizumab is efficacious in reducing bleeding events when compared to on-demand treatment and factor-based prophylaxis. Except for the few thrombotic microangiopathy and thrombotic event cases mainly seen in the HAVEN 1 trial, emicizumab has an overall excellent safety profile with minimal side effects. EXPERT OPINION: Knowledge gaps include the efficacy and safety of emicizumab in younger age groups and those with mild or moderate hemophilia A. Future directions for research include exploring the risk of inhibitor recurrence in patients with a history of high titer inhibitor who have been successfully tolerized, who switch from factor prophylaxis to emicizumab, as well as conducting 'real world studies' to evaluate the patient's perception of emicizumab in regard to ease and tolerability in order to optimize individualized treatment plans.
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Authors | Cassandra P Wang, Guy Young, Courtney D Thornburg |
Journal | Expert opinion on drug safety
(Expert Opin Drug Saf)
Vol. 20
Issue 4
Pg. 387-396
(Apr 2021)
ISSN: 1744-764X [Electronic] England |
PMID | 33612049
(Publication Type: Journal Article, Review)
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Chemical References |
- Antibodies, Bispecific
- Antibodies, Monoclonal, Humanized
- emicizumab
- Factor VIII
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Topics |
- Antibodies, Bispecific
(administration & dosage, adverse effects)
- Antibodies, Monoclonal, Humanized
(administration & dosage, adverse effects)
- Factor VIII
(administration & dosage)
- Hemophilia A
(drug therapy)
- Hemorrhage
(etiology, prevention & control)
- Humans
- Thrombosis
(chemically induced)
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