South American Hemorrhagic Fevers: A summary for clinicians.

Abstract

OBJECTIVES:

This article is one of a series on acute, severe diseases of humans caused by emerging viruses for which there are no or limited licensed medical countermeasures. We approached this summary on South American Hemorrhagic Fevers (SAHF) from a clinical perspective that focuses on pathogenesis, clinical features, and diagnostics with an emphasis on therapies and vaccines that have demonstrated potential for use in an emergency situation through their evaluation in nonhuman primates (NHPs) and/or in humans.

METHODS:

A standardized literature review was conducted on the clinical, pathological, vaccine, and treatment factors for SAHF as a group and for each individual virus/disease.

RESULTS:

We identified 2 treatments and 1 vaccine platform that have demonstrated potential benefit for treating or preventing infection in humans and 4 other potential treatments currently under investigation.

CONCLUSION:

We provide succinct summaries of these countermeasures to give the busy clinician a head start in reviewing the literature if faced with a patient with South American Hemorrhagic Fever. We also provide links to other authoritative sources of information.

• Authors: Maria G Frank, Adam Beitscher, Camille M Webb, Vanessa Raabe, members of the Medical Countermeasures Working Group of the National Emerging Special Pathogens Training and Education Center’s (NETEC’s) Special Pathogens Research Network (SPRN)
• Journal: International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases (Int J Infect Dis) Vol. 105 Pg. 505-515 (Apr 2021) ISSN: 1878-3511 [Electronic] Canada
• PMID: 33610781 (Publication Type: Journal Article, Review)
• Copyright: Copyright © 2021 The Author(s). Published by Elsevier Ltd.. All rights reserved.

Chemical References

• Viral Vaccines

Topics

• Arenaviridae (immunology)
• Hemorrhagic Fever, American (pathology, prevention & control, therapy, virology)
• Humans
• Viral Vaccines (immunology)