Abstract | BACKGROUND: METHODS: We retrospectively reviewed patients who received ECMO for postcardiotomy shock from July 2007 through July 2019. Characteristics of patients who had bleeding and thrombosis were investigated, and risk factors were assessed by multilevel logistic regression. RESULTS: Of the 152 patients who received ECMO for postcardiotomy shock, 33 (23%) had 40 thrombotic events and 64 (45%) had 86 bleeding events. Predictors of bleeding were intraoperative packed red blood cell transfusion (odds ratio [OR] 1.05; 95% confidence interval [CI], 1.01 to 1.09), platelet transfusion (OR 1.10; 95% CI, 1.05 to 1.16), international normalized ratio (OR 1.18; 95% CI, 1.02 to 1.37), and activated partial thromboplastin time greater than 60 seconds (OR 2.32; 95% CI, 1.14 to 4.73). Predictors of thrombosis were anticoagulant use (OR 0.39; 95% CI, 0.19 to 0.79), surgical venting (OR 3.07; 95% CI, 1.29 to 7.31), hemoglobin (OR 1.38; 95% CI, 1.06 to 1.79), and central cannulation (OR 2.06; 95% CI, 1.03 to 4.11). The daily predicted probability of thrombosis was between 0.075 and 0.038 for patients who did not receive anticoagulation and decreased to between 0.030 and 0.013 for patients who received anticoagulation treatment at activated partial thromboplastin times between 25 and 80 seconds. CONCLUSIONS: Anticoagulation therapy can reduce thromboembolic events in postcardiotomy shock patients on ECMO, but bleeding risk may outweigh this benefit at activated partial thromboplastin times greater than 60 seconds.
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Authors | Andrew Melehy, Yuming Ning, Paul Kurlansky, Yuji Kaku, Justin Fried, Jonathan Hastie, Alana Ciolek, Daniel Brodie, Andrew B Eisenberger, Gabriel Sayer, Nir Uriel, Hiroo Takayama, Yoshifumi Naka, Koji Takeda |
Journal | The Annals of thoracic surgery
(Ann Thorac Surg)
Vol. 113
Issue 1
Pg. 131-137
(Jan 2022)
ISSN: 1552-6259 [Electronic] Netherlands |
PMID | 33609547
(Publication Type: Journal Article)
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Copyright | Copyright © 2022 The Society of Thoracic Surgeons. Published by Elsevier Inc. All rights reserved. |
Chemical References |
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Topics |
- Aged
- Anticoagulants
(therapeutic use)
- Extracorporeal Membrane Oxygenation
(adverse effects)
- Female
- Hemorrhage
(etiology)
- Humans
- Logistic Models
- Male
- Middle Aged
- Retrospective Studies
- Risk Factors
- Shock, Cardiogenic
(therapy)
- Thrombosis
(etiology)
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