Abstract |
Characterization of the humoral response to SARS-CoV-2, the etiological agent of COVID-19, is essential to help control the infection. The neutralization activity of plasma from patients with COVID-19 decreases rapidly during the first weeks after recovery. However, the specific role of each immunoglobulin isotype in the overall neutralizing capacity is still not well understood. In this study, we select plasma from a cohort of convalescent patients with COVID-19 and selectively deplete immunoglobulin A, M, or G before testing the remaining neutralizing capacity of the depleted plasma. We find that depletion of immunoglobulin M is associated with the most substantial loss of virus neutralization, followed by immunoglobulin G. This observation may help design efficient antibody-based COVID-19 therapies and may also explain the increased susceptibility to SARS-CoV-2 of autoimmune patients receiving therapies that impair the production of immunoglobulin M ( IgM).
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Authors | Romain Gasser, Marc Cloutier, Jérémie Prévost, Corby Fink, Éric Ducas, Shilei Ding, Nathalie Dussault, Patricia Landry, Tony Tremblay, Audrey Laforce-Lavoie, Antoine Lewin, Guillaume Beaudoin-Bussières, Annemarie Laumaea, Halima Medjahed, Catherine Larochelle, Jonathan Richard, Gregory A Dekaban, Jimmy D Dikeakos, Renée Bazin, Andrés Finzi |
Journal | Cell reports
(Cell Rep)
Vol. 34
Issue 9
Pg. 108790
(03 02 2021)
ISSN: 2211-1247 [Electronic] United States |
PMID | 33596407
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2021 The Author(s). Published by Elsevier Inc. All rights reserved. |
Chemical References |
- Antibodies, Neutralizing
- Antibodies, Viral
- Immunoglobulin A
- Immunoglobulin G
- Immunoglobulin M
- Spike Glycoprotein, Coronavirus
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Topics |
- Adult
- Aged
- Antibodies, Neutralizing
(immunology)
- Antibodies, Viral
(immunology)
- COVID-19
(epidemiology, immunology, therapy)
- Canada
(epidemiology)
- Cohort Studies
- Female
- Humans
- Immunity, Humoral
(immunology)
- Immunization, Passive
(methods)
- Immunoglobulin A
(immunology)
- Immunoglobulin G
(immunology)
- Immunoglobulin M
(blood, immunology, therapeutic use)
- Male
- Middle Aged
- SARS-CoV-2
(immunology)
- Spike Glycoprotein, Coronavirus
(immunology)
- Young Adult
- COVID-19 Serotherapy
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