99mTc-CN7DG: A Highly Expected SPECT Imaging Agent of Cancer with Satisfactory Tumor Uptake and Tumor-to-Nontarget Ratios.

Abstract

A novel glucose derivative (CN7DG) possessing an isonitrile as a coordinating group was synthesized, and 99mTc-CN7DG, which was expected to be a powerful tumor imaging agent for SPECT, was prepared in a kit by the reaction of CN7DG with SnCl2·2H2O and 99mTcO4-. 99mTc-CN7DG exhibited good stability and was transported via glucose transporters. Biodistribution results in mice bearing A549 tumor models showed that 99mTc-CN7DG had a higher uptake at the tumor sites and better tumor/blood and tumor/muscle ratios than did [18F]FDG and 99mTc-CN5DG. SPECT/CT imaging studies showed obvious accumulation in tumor sites, suggesting that 99mTc-CN7DG is a promising candidate for tumor imaging. Because 99mTc and 188Re stand for a "theranostic pair", 188Re-CN7DG is expected to be prepared as a promising agent for tumor therapy.

• Authors: Qianqian Gan, Xuran Zhang, Qing Ruan, Si'an Fang, Junbo Zhang
• Journal: Molecular pharmaceutics (Mol Pharm) Vol. 18 Issue 3 Pg. 1356-1363 (03 01 2021) ISSN: 1543-8392 [Electronic] United States
• PMID: 33586982 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Organotechnetium Compounds
• Radiopharmaceuticals
• Fluorodeoxyglucose F18

Topics

• A549 Cells
• Animals
• Biological Transport (physiology)
• Fluorodeoxyglucose F18 (metabolism)
• Humans
• Mice
• Neoplasms (diagnostic imaging, metabolism)
• Organotechnetium Compounds (metabolism)
• Radiopharmaceuticals (metabolism)
• Single Photon Emission Computed Tomography Computed Tomography (methods)
• Tissue Distribution
• Tomography, Emission-Computed, Single-Photon (methods)