In less than 6 months,
COVID-19 spread rapidly around the world and became a global health concern.
Hypertension is the most common
chronic disease in
COVID-19 patients, but its impact on these patients has not been well described. In this retrospective study, 82 patients diagnosed with
COVID-19 were enrolled, and epidemiological, demographic, clinical, laboratory, radiological and
therapy-related data were analyzed and compared between
COVID-19 patients with (29 cases) or without (53 cases)
hypertension. The median age of the included patients was 60.5 years, and the cohort included 49 women (59.8%) and 33 (40.2%) men.
Hypertension (31 [28.2%]) was the most common
chronic illness, followed by diabetes (16 [19.5%]) and
cardiovascular disease (15 [18.3%]). The most common symptoms were
fatigue (55 [67.1%]), dry
cough (46 [56.1%]) and fever ≥ 37.3 °C (46 [56.1%]). The median time from illness onset to positive RT-PCR test was 13.0 days (range 3-25 days). There were 6 deaths (20.7%) in the
hypertension group and 5 deaths (9.4%) in the nonhypertension group, and more hypertensive patients with
COVID-19 (8 [27.6%]) than nonhypertensive patients (2 [3.8%]) (P = 0.002) had at least one comorbid disease. Compared with nonhypertensive patients, hypertensive patients exhibited higher neutrophil counts,
serum amyloid A,
C-reactive protein, and
NT-proBNP and lower lymphocyte counts and eGFR. Dynamic observations indicated more severe disease and poorer outcomes after hospital admission in the
hypertension group.
COVID-19 patients with
hypertension have increased risks of severe inflammatory reactions, serious internal organ injury, and
disease progression and deterioration.