Abstract | AIM: MATERIAL AND METHODS: 120 Wistar rats underwent ligation around the lower left molar. After seven days, the ligature was removed. The animals were separated into the following groups (n = 15): EP, no treatment; SRP, SRP and irrigation with saline solution; MB, SRP and deposition of MB; TBO, SRP and deposition of TBO; BuTB, SRP and deposition of BuTB; MB-aPDT, SRP and aPDT with MB; TBO-aPDT, SRP and aPDT with TBO and; BuTB-aPDT, SRP and aPDT with BuTB. The aPDT session was performed after SRP, with deposition of the photosensitizer and irradiation with a diode laser (DL; InGaAlP, 660 nm, 40 mW, 60 s, 2.4 J). Histological and histometric analysis was performed. RESULTS: BuTB-aPDT group had a lesser extent of the inflammatory process compared to the EP, SRP, MB and TBO at all experimental periods (p < 0.05). At 15 days, the aPDT treated groups had a greater bone tissue structure than groups EP and SRP (p < 0.05) The BuTB showed lower Alveolar Bone Loss (ABL) compared to the TBO-aPDT group at 30 days (p < 0.05). CONCLUSION: aPDT using the photosensitizer BuTB proved to be the adjuvant therapy that most favored the reduction of inflammatory infiltrate in the furcation area and ABL.
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Authors | Letícia Helena Theodoro, Tiago Esgalha da Rocha, Mark Wainwright, Marta Aparecida Alberton Nuernberg, Edilson Ervolino, Eduardo Quintão Manhanini Souza, Daniela Atili Brandini, Valdir Gouveia Garcia |
Journal | Photodiagnosis and photodynamic therapy
(Photodiagnosis Photodyn Ther)
Vol. 34
Pg. 102198
(Jun 2021)
ISSN: 1873-1597 [Electronic] Netherlands |
PMID | 33578028
(Publication Type: Journal Article)
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Copyright | Copyright © 2021 Elsevier B.V. All rights reserved. |
Chemical References |
- Phenothiazines
- Photosensitizing Agents
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Topics |
- Animals
- Dental Scaling
- Periodontitis
(drug therapy)
- Phenothiazines
(pharmacology, therapeutic use)
- Photochemotherapy
(methods)
- Photosensitizing Agents
(pharmacology, therapeutic use)
- Rats
- Rats, Wistar
- Root Planing
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