Abstract | BACKGROUND: METHODS: One hundred children aged 6 years or more with primary MNE unresponsive to desmopressin treatment were included. The children were randomly divided into two equal groups. Group A received imipramine 25 mg and solifenacin 5-10 mg oral tablets and group B received placebo once 1 h before bedtime for 3 months. The primary end point was to investigate the efficacy of the combined treatment of solifenacin and imipramine and the secondary end point was the safety of the drugs. RESULTS: Our study showed that the mean post treatment wet nights per month was significantly lesser in the treatment group than placebo group (p < 0.001) and cure rate was significantly higher in treatment group than placebo group (p < 0.001). The relapse rate was statistically significantly lower in treatment group than placebo group (p = 0.032). No significant side effects related to the drugs were reported. CONCLUSION:
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Authors | Mohamed Samir, Mahmoud A Mahmoud, Hossam Elawady |
Journal | Urologia
(Urologia)
Vol. 88
Issue 4
Pg. 369-373
(Nov 2021)
ISSN: 1724-6075 [Electronic] United States |
PMID | 33568005
(Publication Type: Journal Article, Randomized Controlled Trial)
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Chemical References |
- Deamino Arginine Vasopressin
- Solifenacin Succinate
- Imipramine
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Topics |
- Child
- Deamino Arginine Vasopressin
- Humans
- Imipramine
(therapeutic use)
- Nocturnal Enuresis
(drug therapy)
- Prospective Studies
- Solifenacin Succinate
(therapeutic use)
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