Morphologic and molecular study on the lens anterior capsule in systemic sclerosis.

Abstract

This study aimed to analyze the anterior lens capsule specimens from both eyes of a patient with systemic sclerosis and compare them to the eyes of a control patient. No significant differences between systemic sclerosis and control eyes were observed in the results from the hematoxylin-eosin and picrosirius staining. In the samples obtained from both systemic sclerosis and control eyes, there were expressions of caspase, a molecule expressed in cell death by apoptosis. Heparanase was overexpressed in the systemic sclerosis sample compared to the control sample. Therefore, the anterior lens capsule of the patient with systemic sclerosis is probably affected by the disease since it showed marked expression of heparanase 1.

• Authors: Beatriz Fiuza Gomes, Armando S Crema, Marcony R Santhiago, Adroaldo Alencar Costa Filho, Haroldo Vieira Moraes Jr, Doralice Silva Paiva, Nádia C O Miguel
• Journal: Arquivos brasileiros de oftalmologia (Arq Bras Oftalmol) 2021 May-Jun Vol. 84 Issue 3 Pg. 271-274 ISSN: 1678-2925 [Electronic] Brazil
• PMID: 33567028 (Publication Type: Letter)

Topics

• Apoptosis
• Cataract
• Humans
• Lens Capsule, Crystalline
• Scleroderma, Systemic
• Staining and Labeling