Sex disparities and neutralizing antibody durability to SARS-CoV-2 infection in convalescent individuals.

Abstract

The coronavirus disease 2019 (COVID-19) pandemic, caused by severe acute respiratory syndrome-related coronavirus-2 (SARS-CoV-2) has now caused over 2 million deaths worldwide and continues to expand. Currently, much is unknown about functionally neutralizing human antibody responses and durability to SARS-CoV-2. Using convalescent sera collected from 101 COVID-19 recovered individuals 21-212 days after symptom onset with forty-eight additional longitudinal samples, we measured functionality and durability of serum antibodies. We also evaluated associations between individual demographic and clinical parameters with functional neutralizing antibody responses to COVID-19. We found robust antibody durability out to six months, as well as significant positive associations with the magnitude of the neutralizing antibody response and male sex. We also show that SARS-CoV-2 convalescent neutralizing antibodies are higher in individuals with cardio-metabolic comorbidities.

• Authors: Alena J Markmann, Natasa Giallourou, D Ryan Bhowmik, Yixuan J Hou, Aaron Lerner, David R Martinez, Lakshmanane Premkumar, Heather Root, David van Duin, Sonia Napravnik, Stephen D Graham, Quique Guerra, Rajendra Raut, Christos J Petropoulos, Terri Wrin, Caleb Cornaby, John Schmitz, JoAnn Kuruc, Susan Weiss, Yara Park, Ralph Baric, Aravinda M de Silva, David M Margolis, Luther A Bartelt
• Journal: medRxiv : the preprint server for health sciences (medRxiv) (Feb 03 2021) United States
• PMID: 33564775 (Publication Type: Preprint)