Leveraging Single-Cell Approaches in Cancer Precision Medicine.

Abstract

Cancer precision medicine aims to improve patient outcomes by tailoring treatment to the unique genomic background of a tumor. However, efforts to develop prognostic and drug response biomarkers largely rely on bulk 'omic' data, which fails to capture intratumor heterogeneity (ITH) and deconvolve signals from normal versus tumor cells. These shortcomings in measuring clinically relevant features are being addressed with single-cell technologies, which provide a fine-resolution map of the genetic and phenotypic heterogeneity in tumors and their microenvironment, as well as an improved understanding of the patterns of subclonal tumor populations. Here we present recent advances in the application of single-cell technologies, towards gaining a deeper understanding of ITH and evolution, and potential applications in developing personalized therapeutic strategies.

• Authors: Aritro Nath, Andrea H Bild
• Journal: Trends in cancer (Trends Cancer) Vol. 7 Issue 4 Pg. 359-372 (04 2021) ISSN: 2405-8025 [Electronic] United States
• PMID: 33563578 (Publication Type: Journal Article, Research Support, N.I.H., Extramural, Review)
• Copyright: Copyright © 2021 Elsevier Inc. All rights reserved.

Topics

• Drug Resistance, Neoplasm
• Genetic Heterogeneity
• Humans
• Neoplasms (genetics, therapy)
• Precision Medicine
• Single-Cell Analysis
• Tumor Microenvironment