Nanostructured Non-Ionic Surfactant Carrier-Based Gel for Topical Delivery of Desoximetasone.

Abstract

Psoriasis is a chronic autoimmune skin disease impacting the population globally. Pharmaceutical products developed to combat this condition commonly used in clinical settings are IV bolus or oral drug delivery routes. There are some major challenges for effectively developing new dosage forms for topical use: API physicochemical nature, the severity of the disease state, and low bioavailability present challenges for pharmaceutical product developers. For non-severe cases of psoriasis, topical drug delivery systems may be preferred or used in conjunction with oral or parenteral therapy to address local symptoms. Elastic vesicular systems, termed "niosomes", are promising drug delivery vehicles developed to achieve improved drug delivery into biological membranes. This study aimed to effectively incorporate a corticosteroid into the niosomes for improving the drug bioavailability of desoximetasone, used to treat skin conditions via topical delivery. Niosomes characterization measurements were drug content, pH, spreadability, specific gravity, content uniformity, rheology, and physicochemical properties. Formulations used a topical gelling agent, Carbomer 980 to test for in vitro skin permeation testing (IVPT) and accelerated stability studies. The developed niosomal test gel provided approximately 93.03 ± 0.23% to 101.84 ± 0.11% drug content with yield stresses ranging from 16.12 to 225.54 Pa. The permeated amount of desoximetasone from the niosomal gel after 24 h was 9.75 ± 0.44 µg/cm2 compared to 24.22 ± 4.29 µg/cm2 released from the reference gel tested. Furthermore, a drug retention study compared the test gel to a reference gel, demonstrating that the skin retained 30.88 ng/mg of desoximetasone while the reference product retained 26.01 ng/mg. A controlled drug release profile was obtained with a niosomal formulation containing desoximetasone for use in a topical gel formulation showing promise for potential use to treat skin diseases like psoriasis.

• Authors: Parinbhai Shah, Benjamin Goodyear, Nirali Dholaria, Vinam Puri, Bozena Michniak-Kohn
• Journal: International journal of molecular sciences (Int J Mol Sci) Vol. 22 Issue 4 (Feb 03 2021) ISSN: 1422-0067 [Electronic] Switzerland
• PMID: 33546426 (Publication Type: Journal Article)

Chemical References

• Drug Carriers
• Gels
• Surface-Active Agents
• Desoximetasone

Topics

• Administration, Cutaneous
• Administration, Topical
• Chemical Phenomena
• Chemistry, Pharmaceutical
• Desoximetasone (administration & dosage)
• Dose-Response Relationship, Drug
• Drug Carriers (chemistry)
• Drug Delivery Systems
• Drug Stability
• Gels (chemistry)
• Humans
• Hydrogen-Ion Concentration
• Kinetics
• Nanostructures (chemistry)
• Permeability
• Skin (drug effects, metabolism)
• Skin Absorption
• Surface-Active Agents (chemistry)
• Viscosity