Twenty years of pediatric diabetes surveillance: what do we know and why it matters.

Abstract

SEARCH for Diabetes in Youth (SEARCH) was initiated in 2000 as a multicenter study to address major gaps in the understanding of childhood diabetes in the United States. An active registry of youth diagnosed with diabetes at age <20 years since 2002 assessed prevalence, annual incidence, and trends by age, race/ethnicity, sex, and diabetes type. An observational cohort nested within the population-based registry was established to assess the natural history and risk factors for acute and chronic diabetes-related complications, as well as the quality of care and quality of life of children and adolescents with diabetes from diagnosis into young adulthood. SEARCH findings have contributed to a better understanding of the complex and heterogeneous nature of youth-onset diabetes. Continued surveillance of the burden and risk of type 1 and type 2 diabetes is important to track and monitor incidence and prevalence within the population. SEARCH reported evidence of early diabetes complications highlighting that continuing the long-term follow-up of youth with diabetes is necessary to further our understanding of its natural history and to develop the most appropriate approaches to primary, secondary, and tertiary prevention of diabetes and its complications. This review summarizes two decades of research and suggests avenues for further work.

• Authors: Dana Dabelea, Katherine A Sauder, Elizabeth T Jensen, Amy K Mottl, Alyssa Huang, Catherine Pihoker, Richard F Hamman, Jean Lawrence, Lawrence M Dolan, Ralph D' Agostino Jr, Lynne Wagenknecht, Elizabeth J Mayer-Davis, Santica M Marcovina
• Journal: Annals of the New York Academy of Sciences (Ann N Y Acad Sci) Vol. 1495 Issue 1 Pg. 99-120 (07 2021) ISSN: 1749-6632 [Electronic] United States
• PMID: 33543783 (Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S., Review)
• Copyright: © 2021 New York Academy of Sciences.

Topics

• Adolescent
• Child
• Child, Preschool
• Diabetes Complications (epidemiology, mortality)
• Diabetes Mellitus, Type 1 (epidemiology, pathology)
• Diabetes Mellitus, Type 2 (epidemiology, pathology)
• Epidemiological Monitoring
• Humans
• Incidence
• Infant
• Observational Studies as Topic
• Prevalence
• Registries
• United States (epidemiology)