Sofosbuvir-velpatasvir in Mexican patients with hepatitis C: A retrospective review.

Abstract

INTRODUCTION:

The sofosbuvir-velpatasvir (SOF/VEL) combination is a direct-acting antiviral therapy that is authorized and available in Mexico, making the performance of a real-world multicenter study that evaluates the sustained virologic response at 12 weeks post-treatment a relevant undertaking.

METHODS:

A retrospective review of the case records of 241 patients seen at 20 hospitals in Mexico was conducted to assess hepatitis C treatment with the SOF/VEL combination (n = 231) and the sofosbuvir/velpatasvir/ribavirin (SOF/VEL/RBV) combination (n = 10). The primary efficacy endpoint was the percentage of patients that achieved SVR at 12 weeks after the end of treatment.

RESULTS:

Overall SVR was 98.8% (95% CI 97.35-100%). Only three patients did not achieve SVR, two of whom had cirrhosis and a history of previous treatment with peg-IFN. Of the subgroups analyzed, all the patients with HIV coinfection, three patients with genotype 3, and the patients treated with the SOF/VEL/RBV combination achieved SVR. The subgroups with the lower success rates were patients that were treatment-experienced (96.8%) and patients with F1 fibrosis (95.5%). The most frequent adverse events were fatigue, headache, and insomnia. No serious adverse events were reported.

CONCLUSION:

Treatments with SOF/VEL and SOF/VEL/RBV were highly safe and effective, results coinciding with those of other international real-world studies.

• Authors: J L Pérez-Hernández, C A Arce-Salinas, R Lehmann-Mendoza, A Torre-Delgadillo, G E Castro-Narro, E Cerda-Reyes, M V Ramos-Gómez, L Juárez-Chavez, M Dehesa-Violante, L E Muñoz-Espinosa, L E Cisneros-Garza, I Aiza-Haddad, J A Velarde-Ruiz-Velasco, R Contreras-Omaña, N García-Casarreal, A Carmona-Castañeda, F Higuera-De la Tijera
• Journal: Revista de gastroenterologia de Mexico (English) (Rev Gastroenterol Mex (Engl Ed)) (Jan 30 2021) ISSN: 2255-534X [Electronic] Mexico
• Vernacular Title: Sofosbuvir-velpatasvir en pacientes mexicanos con hepatitis C: una revisión retrospectiva.
• PMID: 33531165 (Publication Type: Journal Article)
• Copyright: Copyright © 2020 Asociación Mexicana de Gastroenterología. Publicado por Masson Doyma México S.A. All rights reserved.