PET-CT radiomics by integrating primary tumor and peritumoral areas predicts E-cadherin expression and correlates with pelvic lymph node metastasis in early-stage cervical cancer.

Abstract

OBJECTIVES:

To explore the role of radiomics in integrating primary tumor and peritumoral areas based on PET-CT scans for predicting E-cadherin (E-cad) expression in early-stage cervical cancer (ESCC) and its correlation with pelvic lymph node metastasis (PLNM).

METHODS:

Ninety-seven ESCC patients who had undergone PET-CT scans were retrospectively analyzed. The ROI of primary tumors, peritumoral areas, and plus tumors were semi-automatically segmented on PET-CT images. A total of 1188 radiomics features were extracted, selected, and eventually integrated into radiomics score (rad-score). The rad-score difference between patients with E-cad expression of high and low was analyzed using Mann-Whitney tests. Characteristic correlation was tested using a Spearman analysis. Four models were established using logistic regression algorithms and evaluated using ROC and calibration curves. A DeLong test was used to perform pairwise comparisons of AUCs.

RESULTS:

The rad-score of patients with low E-cad expression was higher than that of patients with high E-cad expression in both training and testing cohorts (p < 0.001 and p = 0.027, respectively). A significant correlation was observed between the rad-score and E-cad (p < 0.001). PLNM correlated slightly with rad-score and E-cad values (p = 0.01 and p < 0.001, respectively). The ROC curve and calibration curve of the rad-score model performed best in both training and testing cohorts (AUC = 0.915, 0.844, p < 0.001, respectively).

CONCLUSIONS:

The radiomics of integrating primary tumor and peritumoral areas based on PET-CT showed correlations with PLNM. It was also able to predict E-cad expression in ESCC patients, allowing for evaluation of those patients' prognosis and more individualized medical treatment.

KEY POINTS:

• By integrating the primary tumor and peritumoral area based on PET-CT, radiomics was feasible. • The rad-score was associated with E-cad expression and PLNM in patients with ESCC. • Radiomics that integrated the primary tumor and peritumoral areas based on PET-CT could predict E-cad expression in patients with ESCC.

• Authors: Xiao-Ran Li, Jun-Jie Jin, Yang Yu, Xing-Hao Wang, Yan Guo, Hong-Zan Sun
• Journal: European radiology (Eur Radiol) Vol. 31 Issue 8 Pg. 5967-5979 (Aug 2021) ISSN: 1432-1084 [Electronic] Germany
• PMID: 33528626 (Publication Type: Journal Article)
• Copyright: © 2021. European Society of Radiology.

Chemical References

• Antigens, CD
• CDH1 protein, human
• Cadherins

Topics

• Antigens, CD
• Cadherins
• Female
• Humans
• Lymphatic Metastasis
• Positron Emission Tomography Computed Tomography
• Retrospective Studies
• Uterine Cervical Neoplasms (diagnostic imaging)