Cardiac resynchronization therapy in paediatric patients with congenital heart disease: single centre with 10 years of experience.

Abstract

OBJECTIVES:

In recent years, cardiac resynchronization therapy (CRT) has also started to be performed in the paediatric and CHD population. This study aimed to evaluate the efficacy of CRT in children with CHD.

PATIENTS AND METHODS:

Patients with CHD who underwent CRT treatment in our paediatric cardiology clinic between January, 2010 and January, 2020 were included in the study. Demographic findings, 12-lead electrocardiograms, echocardiograms, clinical characteristics, management strategies, and outcomes were reviewed systematically.

RESULTS:

The study population consisted of 18 CHD patients who had been treated with CRT for 10 years in our institution. The median age was 11 years (2.2-18 years) and the median weight was 39 kg (10-81 kg). Systemic ventricle was left ventricle in 13 patients, right ventricle in 4 patients, and 1 patient had single-ventricle physiology. CRT implantation indications were as follows: dysfunction after permanent pacemaker in 11 patients, dysfunction after left bundle branch block in 4 patients, and systemic ventricular dysfunction in 3 patients. CRT implantation techniques were epicardial (n = 13), hybrid (n = 4), and transvenous (n = 1) methods. QRS duration significantly decreased after CRT implantation (160 versus 124 m/second, p < 0.05). Median systemic ventricle ejection fraction (EF) significantly increased after the procedure (30 versus 50%, p < 0.05). Fourteen patients (78%) were responders, two patients (11%) were superresponders, and two patients (11%) were non-responders after the CRT treatment. One patient deceased during follow-up. Median follow-up duration was 40 months (6-117 months).

CONCLUSION:

When electromechanical dyssynchrony occurs in paediatric cases with CHD and developing heart failure, patients should be evaluated in terms of CRT to improve ventricular function. Alternative CRT therapy will be beneficial in these cases that do not improve clinically despite optimal medical treatment.

• Authors: Yakup Ergul, Fatma Sevinc Sengul, Erkut Öztürk, Hasan C Kafalı, Pelin Ayyıldız, Ibrahim C Tanıdır, Halil S Akdeniz, Mustafa Güneş, Okan Yıldız, Sertaç Haydin, Alper Güzeltaş
• Journal: Cardiology in the young (Cardiol Young) Vol. 31 Issue 6 Pg. 940-948 (Jun 2021) ISSN: 1467-1107 [Electronic] England
• PMID: 33500007 (Publication Type: Journal Article)

Topics

• Bundle-Branch Block
• Cardiac Resynchronization Therapy
• Child
• Heart Defects, Congenital (complications, therapy)
• Heart Failure (therapy)
• Humans
• Retrospective Studies
• Treatment Outcome