Abstract |
Induced pluripotent stem cells (iPSCs), reprogrammed from human somatic cells, hold the capacity to differentiate into most human body cells. iPSCs can be differentiated into retinal organoids, a three-dimensional structured retina containing various retinal cells. Patient-specific retinal organoids provide a powerful disease model to recapitulate the disease to study the pathogenesis of inherited retinal dystrophies, to screen or discover new drugs, and most importantly to supply an unlimited cell source for retinal regeneration.
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Authors | Xiao-Hui Zhang, Zi-Bing Jin |
Journal | Histology and histopathology
(Histol Histopathol)
Vol. 36
Issue 7
Pg. 705-710
(Jul 2021)
ISSN: 1699-5848 [Electronic] Spain |
PMID | 33491763
(Publication Type: Journal Article, Review)
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Topics |
- Animals
- Cell Culture Techniques
(methods)
- Humans
- Induced Pluripotent Stem Cells
- Organoids
- Retina
- Retinal Diseases
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